ClinVar Missense 3D Visualizer

Missense variants on AlphaFold structures · ClinVar + UniProt + AFDB + AlphaMissense, all client-side

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Missense variants

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Structure pLDDT: low ←→ high
Select a variant from the list (or click a sphere in 3D) to see details.
About the data & how to cite
Data: ClinVar (NCBI E-utilities) · UniProt REST · AlphaFold DB · AlphaMissense via MyVariant/dbNSFP · rendered with 3Dmol.js. See README for full citations. Residue numbers come from ClinVar HGVS p. (RefSeq-based); if the RefSeq isoform differs from UniProt canonical, the app shows a mismatch warning.